Deniz Arik
Eskisehir Osmangazi University, Turkey
Title: Water-clear cell adenoma of the mediastinal parathyroid gland
Biography
Biography: Deniz Arik
Abstract
Water-clear cell adenoma is composed of cells with abundant clear-pink cytoplasm. It is postulated that the water-clear cells are transformed from the chief cells. We report a mediastinal water-clear cell adenoma of the parathyroid gland. At microscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, arranged in solid and acinar patterns were revealed. The cells form nests separated by fine fibrovascular septae and stain positively with anti-parathyroid hormone. Primary hyperparathyroidism is characterized by the autonomous production of parathyroid hormone resulting in hypercalcemia. It is most commonly seen with sporadic adenomas, followed by hyperplasia, multiple adenomas, and carcinoma. Water-clear cell parathyroid adenoma is extremely rare. There have only 16 cases were reported in the English literature. To the best of our knowledge this has not been reported previously in this localisation. In differential diagnosis of clear cell lesions of the mediastinum, WCCA should be kept in mind.