Masoumeh Sadeghi
Isfahan University of Medical Sciences, Iran
Title: Metabolic syndrome and menopausal status: Isfahan Healthy Heart Program, a large population based survey
Biography
Biography: Masoumeh Sadeghi
Abstract
Introduction- There is an increase in cardiovascular disease after menopause. On the other hand, metabolic syndrome as a collection of risk factors has a known effect on cardiovascular problems. Hormone changes are considered as one of the essential factor regarding cardiovascular disease as well as some recognized relationship with metabolic syndrome’s components. This study was carried out in order to evaluate prevalence of metabolic syndrome during menopausal transition. Method- In a cross sectional study in urban and rural areas of Isfahan, Najafabad and Arak cities, 1596 women aged more than 45 years were investigated using Isfahan Healthy Heart Program’s (IHHP) samples. Participants were categorized into three groups of pre-menopause, menopause and post-menopause. Leisure time physical activity and global dietary index were included as life style factors. The association of metabolic syndrome and its components with menopausal transition considering other factors such as age and life style was analyzed. Results- There were 303, 233 and 987 women in premenopausal, early menopausal and postmenopausal groups respectively. Metabolic syndrome was found in 136(44.9%) premenopausal participants and significantly increased to 135(57.9%) and 634(64.3%) in early menopausal and postmenopausal participants respectively, when age was considered (P = 0.010). Except for high blood pressure and high triglyceride level, there was no significant difference between three groups of menopausal transition when metabolic syndrome’s components were considered. Conclusion- In contrary to the claims regarding the role of waist circumference and blood glucose in increasing of metabolic syndrome during the menopausal transition, this study showed this phenomenon could be independence process